Macaroni and cheese is a popular Earth recipe, comprised of a pasta, called macaroni, combined with melted cheese.
It was one of the favorite foods of Eddie Tighe. He chose it for dinner when his mother captain Kathryn Janeway allowed him to choose. (MLN: "Final Frontier")
It was one of the few foods that captain Kathryn Janeway knew how to properly program into the replicator. The simple dish was one of the ones she and her fellow cadets practically lived on while they where in Starfleet Academy. (MLN: "Final Frontier")